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Several main mechanisms were suggested by which obesity mediates insulin resistance, including altered secretion patterns of adipocytokines, increased levels of glucocorticoids in visceral fat tissue, and increased secretion of pro-inflammatory agents [35, 37]

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ABCB4 variants were associated with ICP (75%) and chronic liver disease (71.7%), with more severe genotypes correlating with an earlier onset

doi: 10.1007/s10753-021-01514-y, 154 ZengN.WuF.LuJ.LiX.LinS.ZhouL.et al

Kramer, H